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Archive for the ‘Levels’ Category

The following is a recent paper by Henry Heng published in JAMA.  I’ve linked concepts mentioned in the paper to corresponding explications from this blog.


JAMA. 2008;300(13):1580-1581.
The Conflict Between Complex Systems and Reductionism
Henry H. Q. Heng, PhD
Author Affiliations: Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan.

Descartes’ reductionist principle has had a profound influence on medicine. Similar to repairing a clock in which each broken part is fixed in order, investigators have attempted to discover causal relationships among key components of an individual and to treat those components accordingly. (more…)

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Will Wright’s demo of Spore illustrates some key concepts of complex systems, including the notion of simple rules generating complex behaviors, and also the power of recursively applied (i.e. fractal) computation at different levels.  Living systems leverage these same principles.
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I figured it was time for a reset and so the following is a summary of much of the foundational posting that I’ve done on this blog so far.  As always, a work in progress, subject to refinement and learning…

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[ This is an edited version of a blog comment on Brandon Kein’s Wired Science post here ]

The question of whether we will “break through” to a superorganism or collapse through any number of spiraling cascades or catastrophic events is the subject of Ervin Laszlo’s book, The Chaos Point, which I highly recommend.  In it, he gives a sweeping view of the complex evolutionary dynamic (focusing on human society), and makes a solid argument that we are at an inflection point in history right now, similar to the “saltation” that begat multicellularity.
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Here are some notes that I took at TED 2008.  I have a bunch more on each of the speakers individually which I may post as time permits.  Let me know if you want me to expand any of the notes below into a full post.

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Not having had any serious biological training I have to go to Wikipedia and Google to learn the basics. And I’m often surprised to find that concepts everyone uses don’t have good consensus amongst scientists. When reading the Wikipedia entry for “gene”, it occurs to me that if the concept didn’t predate the discovery of DNA, it would not exist.

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Stability can be thought of as a measure of agency. That is, the more stable a system is, the better we are able to recognize it as a distinct agent, a system that actively, structurally or by happenstance persists through time, space and/or other dimensions. Burton Voorhees defines a concept of virtual stability as a “state in which a system employs self-monitoring and adaptive control to maintain itself in a configuration that would otherwise be unstable.” He clarifies that virtual stability is not the same as stability or metastability and gives formal definitions of all three.* By making a distinction between stability, metastability and virtual stability, we can gain further clarity on agency itself and the emergence of new agents and new levels of organization. (more…)

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