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Archive for the ‘Medical Breakthroughs’ Category

In Juan Enriquez’ TED talk earlier this year, he made the point that humans have entered a new phase of evolution, one that has not been seen on before modern humans and their technology.  This, of course, is one of the main theses of Ray Kurzweil’s book, The Singularity is Near, and the main justification for the creation of The Singularity Institute (plus related Singularity Summit), and now just recently, Singularity University.

Lest you think the concept of Homo Evolutis — a species that can control its own evolutionary path by radically extend healthy human lifespan and ultimately merging with its technology — is a fringe concept share by sci-fi dreamers who don’t have a handle on reality, check out the list of people in charge of Singularity University (link above), the Board members of the Lifeboat Foundation, and throw in Stephen Hawking for good measure, who says, “Humans Have Entered a New Phase of Evolution“.  These people not only have a handle on reality, they have the combined power, resources and influence to shape reality.

For those who are still skeptical of the premise of Homo Evolutis, I present the strongest piece of evidence yet: it’s been featured on The Oprah Show.  QED?

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Has anyone played Foldit, the protein-folding game that is designed to advance the science?  This Wired article makes it sound like Ender’s Game meets biochemistry!  Sounds like the Poehlman kid is the protein-folding equivalent of Stephen Wiltshire.  I love the crowdsourcing, the meta-evolutionary algorithm of it (to find the savants), and the implications for science.

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If, like Aubrey de Grey, you believe that immortality is achievable, or you are just intrigued by the possibility, you should check out this news story on The Methuselah Foundation.

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Despite hundreds of billions of dollars appropriated for cancer research, as well as the efforts of thousands of the world’s best minds, progress in preventing or curing cancer has been almost non-existent. I find this unacceptable. We should be doing better. We need to be doing better. So what’s the problem? and more importantly, how can we fix it?

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When I was 16, I dislocated my elbow.  The ensuing re-injuries and calcification of the ligaments ended my competitive wrestling career.  Last year, I separated my shoulder and while it’s pretty well healed, it’s going to have some annoying weaknesses the rest of my life.

I’m not the only one.  Most of the people I know who have been reasonably active through age 40 have some sort of permanent impairment from a ligament, cartilage, or tendon injury.  Today, I was wondering if extracellular matrix (ECM) might be the answer.

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The import of this talk goes way beyond the specific and stunning work that Bassler and her team have done on quorum sensing.  In my mind, this is the prototype for good biological science:

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I happened to come across two interesting posts with Singularity implications that I thought you might be interested in.  First, the Singularity Hub reports that Osiris has a promising phase II trial underway for a treatment that uses foreign stem cells to repair the muscle damage from heart attacks.  If you’re about 40 like Rafe and I, this means your chances of dying from heart disease could go way down.  Now if we can just make some progress on cancer, we’ll be centenarians.

Second, via Prometheus, Wired reports on a robot-software combination that was able to generate, test, and refine it’s own hypotheses to identify coding for orphan enzymes in yeast. Obviously, this is a very special purpose kind of science.  But the fact they got a closed loop is very impressive.  I also like the fact that it’s in the biological sciences. Hey, maybe some descendant of this program can solve the aformentioned cancer problem.

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